Virgin Lady Church is close to central Qamishlo, part of a strip of land controlled by Damascus that halves the city, along with territory on its southwest outskirts.
The rest is controlled by the US-backed and Kurdish-led Syrian Democratic Forces (SDF).
No group has yet claimed responsibility for the attack.
In mid-June, an explosion targeted the main headquarters of the Internal Security Forces in Qamishlo near the city central roundabout, known as Sony, injuring two.
Related Article: Explosion hits Syrian Kurdish city, injuries reported
Security forces and ambulances rushed to the scene, from where smoke could be seen rising, where severe damage to surrounding buildings could be seen.
On July 27, 2016, a truck bomb blast in Qamishlo claimed by the Islamic State took the lives of nearly 50 people and wounded about 150 others.
In recent history, Qamishlo is best known as the site of a 2004 event that first ignited an uprising in northeastern Syria that rapidly spread across other Kurdish-majority areas.
At the time, it was arguably one of the most formative events of Syrian Kurdish political awareness in two decades.
The incident that sparked the uprising began during a seemingly uneventful football match between two rivals: Fetuwa, mainly supported by Arabs, and al-Jihad, supported by Kurds.
In the Qamishlo stadium, Fetuwa fans attacked many Kurdish fans as did Syrian security forces, leaving six Kurds dead.
Three children also died in the ensuing stampede trying to escape the stadium.
Editing by John J.